The Genetics Research Center (GRC) is an AbbVie center of excellence for genetics and genomics that supports both Discovery and Development. The GRC plays an integral role towards the goal of developing world class genetics and genomics research, with a focus on finding the right targets, understanding human disease biology, and investigating the behavior of and response to our drugs in clinical trials. As one of the pillars of the GRC, the Department of Human Genetics is responsible for analyzing and interpreting data from large genetic databases to identify and characterize novel targets for the treatment of diseases across multiple therapeutic areas. We have an exciting opportunity for a Senior Scientist, based in North Chicago, IL, to join a team of geneticists, molecular and cellular biologists, and computational biologists.
Devise and execute studies to determine genotype-phenotype relationships from large, human genetic databases;
Work closely with computational biologists and others to develop and provide analytical support for mining and interpreting NGS and array data;
Provide biological interpretation for genetic, genomic and epigenetic associations derived from large scale human genetic databases;
Collaborate with functional genomics colleagues to design and execute studies to provide mechanistic understanding for genotype-phenotype relationships;
Collaborate with scientists across different Early Discovery therapeutic areas to interpret and incorporate genetic findings into new target discovery or for validation of existing targets;
Provide support for external collaborations and consortia.
Level is commensurate with experience.
BS, MS, PhD or MD in Human Genetics, Molecular Genetics, or closely related field, with expertise in genetic association studies with 10+ (BS), 8+ (MS), or 0+ (PhD/MD) years of experience
Strong background in genetic association studies (GWAS and PheWAS).
Demonstrated ability to design and lead human genetics studies delivering novel genetic findings and medically relevant gene discoveries.
Additional desired skills include:
Experience working with large human genetic databases;
Experience interpreting family-based or rare disease genetic studies;
Experience with large-scale research projects involving next generation DNA sequencing data (e.g. whole exome and whole genome) as well as array-based genotype data;
Strong oral and written communication skills in a collaborative environment.