Postdoctoral position in corneal dystrophies and biology
Stein Eye Institute, UCLA
Location: Los Angeles, California
Type: Full Time
Preferred Education: Doctorate
Years of Experience:
Less than 2
A postdoctoral position is available in the Cornea Genetics Laboratory at the Stein Eye Institute on the University of California, Los Angeles campus. The candidate will have a strong interest in translational research that involves integrating clinical findings with basic science research. The Cornea Genetics Lab focuses on identifying and characterizing the genetic basis of inherited disorders of the cornea (the corneal dystrophies) by utilizing classic and cutting-edge technologies. This is accomplished by using cell based methods (including the use of primary and immortalized corneal endothelial cells) and in vivo experiments using mouse models of inherited corneal disorders.
More information can be found at: https://www.uclahealth.org/eye/cornea-genetics
Candidates are expected to hold a Ph.D and/or M.D. with less than 2 years of postdoctoral experience, be self-motivated and demonstrate a record of research achievement. A strong background in cell biology, molecular biology, genetics and/or molecular cytogenetics is highly preferred. Expertise in cell culture, primary cell isolation, cell transfection, cell-based assays, nucleic acid and protein manipulation, high-throughput data analysis and proficiency in microscopy are necessary, and proficiency with working on mouse models is highly desirable.
Interested individuals who meet the above criteria may apply by sending their CV to:
Anthony J. Aldave, M.D. Professor of Ophthalmology Walton Li Chair in Cornea and Uveitis Chief, Cornea and Uveitis Division Email: [email protected]
The Cornea Genetics Laboratory, under Dr. Aldave's direction, focuses on identifying and characterizing the molecular genetic basis of corneal dystrophies, and elucidating the normal and disease biology of corneal endothelial cells.
The Laboratory employs an array of genetic analysis tools to identify causative mutations associated with inherited corneal disorders, and utilizes mouse and cell-based disease models to study the pathomechanisms via which the identified mutations lead to loss of corneal clarity, and thus loss of vision. The identification and elucidation of the genetic basis of the corneal dystrophies has allowed Dr Aldave and colleagues to develop and test molecular therapeutics approaches in these same cell-based and animal models.
The Laboratory is also involved in the characterization and optimization of ex vivo expansion of corneal endothelial cells, with the goal of transplanting the cells from one individual to multiple recipients. As it is estimated that worldwide only one donor cornea is available for every 70 that are needed, the use of expanded corneal endothelial cells to restore sight to individuals with corneal endothelial dysfunction, most commonl...y due to corneal endothelial dystrophies, will transform the current paradigm of one donor cornea restoring sight to only one recipient.